在國家科技部和中科院的資助下，中科院合肥物質(zhì)科學(xué)研究院智能所采用杯狀大環(huán)物環(huán)糊精對農(nóng)藥殘留分子的有效捕捉，實(shí)現(xiàn)了農(nóng)殘分子的痕量檢測，克服了農(nóng)藥殘留檢測中靈敏性與選擇性的難題。相關(guān)成果的論文已正式發(fā)表在英國*化學(xué)學(xué)會（RSC）的J. Mater. Chem.期刊上，并特別被英國*化學(xué)會期刊Chemical Technology作為Application Highlights（應(yīng)用亮點(diǎn)，5月24日），以Raman fingerprint for insecticide detection（拉曼指紋峰用于農(nóng)殘檢測）為題加以專題報(bào)道，同時(shí)還在其電子期刊Chemistry World上進(jìn)行了新聞報(bào)道。

目前，探索土壤，地下水，食品中的農(nóng)藥殘留的新檢測手段，正在受到廣泛的興趣與關(guān)注，但是要實(shí)現(xiàn)集靈敏度，選擇性與低成本的簡單易行的檢測方法是相當(dāng)困難的。

智能所仿生納米傳感器實(shí)驗(yàn)室王進(jìn)副研究員與其合作者孔令濤博士后等人，利用一維金納米顆粒*的光學(xué)特性，合成了不同長寬比的一維金納米顆粒，進(jìn)行了無碳鏈的環(huán)糊精修飾，在zui接近金表面的區(qū)域富集農(nóng)殘分子，依據(jù)拉曼特征指紋峰，對農(nóng)殘分子進(jìn)行識別探測。該項(xiàng)成果運(yùn)用了表面增強(qiáng)拉曼技術(shù)，借助于納米尺寸的貴金屬表面特殊的拉曼增強(qiáng)效應(yīng)，選取了特定長寬比的一維納米金顆粒，形象地作為光棒起到了對進(jìn)出光子的放大作用，以起到增強(qiáng)待測農(nóng)殘分子的拉曼振動信號。進(jìn)一步通過金棒表面環(huán)糊精的修飾對農(nóng)殘分子進(jìn)行富集選擇，可以形象地比喻為鎖匙效應(yīng)，即某些待測農(nóng)殘分子被有效地捕捉進(jìn)入環(huán)糊精的口袋中，借此克服了農(nóng)藥殘留檢測中靈敏性與選擇性的難題。

在上述工作基礎(chǔ)上，智能所的研究組還將進(jìn)一步合成設(shè)計(jì)不同杯腔的有機(jī)物對具有特殊光學(xué)特性的貴金屬納米顆粒進(jìn)行修飾、組裝，以實(shí)現(xiàn)對農(nóng)藥殘留的超敏感檢測。

推薦原文出處：

J.Mater.Chem., DOI: 10.1039/c0jm00040j

Synthesis of novel decorated one-dimensional gold nanoparticle and its application in ultrasensitive detection of insecticide
Jin Wang, LingTao Kong, Zheng Guo, JingYao Xu and JinHuai Liu

Contamination of soil, groundwater and food with methyl parathion, which is one of the most hazardous insecticides, is causing wide concern. Motivated by the urgent demand for trace analysis of insecticide from environmental samples, searching for a novel highly sensitive or selective analytical approach has been a longstanding interest. The as-prepared one dimensional gold nanoparticles, with different aspect ratios, have been decorated with mono-6-thio--cyclodextrin so as to efficiently capture and detect methyl parathion insecticide via a surface enhanced Raman scattering （SERS） technique for the first time. A detailed comparison among different aspect ratios of the one dimensional gold nanoparticles suggests that the one dimensional gold nanoparticles with aspect ratio 2 can be provided as an excellent SERS active substrate for detecting the insecticide in the present study. Due to the efficient formation of a host–guest complex between the hybridized cavity and methyl parathion, identification of the insecticide can be observed at picomolar level according to the fingerprint Raman peaks. Excellent sensitivity and selectivity for detection of the insecticide using the hybridized one dimensional gold nanoparticles without a Raman label indicate that it is a simple and ultrasensitive approach for detecting insecticides in contrast with some other traditional detection approaches.